Multi-arm response-adaptive designs for circular responses

Authors

Atanu Biswas, Indian Statistical Institute, Kolkata
Rahul Bhattacharya, University of Calcutta
Taranga Mukherjee, University of Calcutta

Article Type

Research Article

Publication Title

Journal of the Korean Statistical Society

Abstract

A multi-arm response-adaptive allocation design is developed for circular treatment outcomes. Several exact and asymptotic properties of the design are studied. Stage-wise treatment selection procedures based on the proposed response-adaptive design are also suggested to exclude the worse performing treatment(s) at earlier stages. Detailed simulation study is carried out to evaluate the proposed selection procedures. The applicability of the proposed methodologies is illustrated through a real clinical trial data on cataract surgery.

First Page

524

Last Page

536

DOI

10.1016/j.jkss.2019.03.005

Publication Date

12-1-2019

Recommended Citation

Biswas, Atanu; Bhattacharya, Rahul; and Mukherjee, Taranga, "Multi-arm response-adaptive designs for circular responses" (2019). Journal Articles. 605.
https://digitalcommons.isical.ac.in/journal-articles/605