Response-adaptive designs for continuous treatment responses in phase III clinical trials: A review

Authors

Atanu Biswas, Indian Statistical Institute, Kolkata
Rahul Bhattacharya, West Bengal State University

Article Type

Research Article

Publication Title

Statistical Methods in Medical Research

Abstract

A variety of response-adaptive randomization procedures have been proposed in literature assuming binary outcomes. However, the list is not so long for continuous outcomes though many real clinical trials deal with continuous treatment responses. In this paper, we attempt to explore the available procedures together with a comparison of their performances. Some real-life adaptive trial is also reviewed.

First Page

81

Last Page

100

DOI

10.1177/0962280212441424

Publication Date

2-1-2016

Recommended Citation

Biswas, Atanu and Bhattacharya, Rahul, "Response-adaptive designs for continuous treatment responses in phase III clinical trials: A review" (2016). Journal Articles. 4411.
https://digitalcommons.isical.ac.in/journal-articles/4411