Near efficient target allocations in response-adaptive randomization

Article Type

Research Article

Publication Title

Statistical Methods in Medical Research

Abstract

Traditionally optimal target allocation proportions for response-adaptive designs are derived by completely ignoring the actual adaptive randomization procedure. Considering efficiency of the allocation designs, we derive near efficient target proportions to balance between individual and collective ethics. Performance of the derived allocation targets are assessed numerically for binary, normal and exponential responses. Generalization for multiple treatments is also addressed.

First Page

807

Last Page

820

DOI

10.1177/0962280212468378

Publication Date

4-1-2016

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