Molecular phylogeny and missense mutations at envelope proteins across coronaviruses
Envelope (E) protein is one of the structural viroporins (76–109 amino acids long) present in the coronavirus. Sixteen sequentially different E-proteins were observed from a total of 4917 available complete SARS-CoV-2 genomes as on 18th June 2020 in the NCBI database. The missense mutations over the envelope protein across various coronaviruses of the β-genus were analyzed to know the immediate parental origin of the envelope protein of SARS-CoV-2. The evolutionary origin is also endorsed by the phylogenetic analysis of the envelope proteins comparing sequence homology as well as amino acid conservations.
Hassan, Sk Sarif; Choudhury, Pabitra Pal; and Roy, Bidyut, "Molecular phylogeny and missense mutations at envelope proteins across coronaviruses" (2020). Journal Articles. 76.