Odds ratio based two-stage group sequential analysis for two-treatment two-period crossover trials

Article Type

Research Article

Publication Title

Communications in Statistics Case Studies Data Analysis and Applications

Abstract

We consider a two-treatment and two-period crossover design where the treatment responses are binary. The outcome from each patient under such trial can be represented by a two-component vector which follows a bivariate binomial distribution. We develop a two-stage group sequential test procedure for equivalence based on the estimates of odds ratio. Various error spending functions are studied in this context. Simulation studies are carried out. An illustration with some real data example is also given.

First Page

300

Last Page

313

DOI

10.1080/23737484.2019.1648192

Publication Date

10-2-2019

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