Association of rs11643718 SLC12A3 and rs741301 ELMO1 Variants with Diabetic Nephropathy in South Indian Population
Article Type
Research Article
Publication Title
Annals of Human Genetics
Abstract
This study reports on the association of genetic variants selected from previous genome-wide association studies for type 2 diabetic nephropathy in south Indians. Eight variants were genotyped in 601 type 2 diabetic subjects without nephropathy (DM) and 583 type 2 diabetic subjects with nephropathy (DN) by MassARRAY. The minor allele frequencies of rs11643718 SLC12A3 variant and rs741301 ELMO1 variant were significantly different between DM and DN groups (P = 0.029 and 0.016, respectively). A combined analysis showed that the subjects carrying the risk genotypes of both these variants (GG of rs11643718 + AG/AA of rs741301) had a significant association with DN with an odds ratio [adjusted for age, sex, Body Mass Index (BMI), HbA1c, and systolic Blood Pressure (BP)] of 1.73 (1.30–2.30, P = 1.72 × 10–4) as compared to subjects carrying all other genotype combinations. This is the first study to report a significant association of the SLC12A3 rs11643718 and ELMO1 rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.
First Page
336
Last Page
341
DOI
10.1111/ahg.12174
Publication Date
11-1-2016
Recommended Citation
Bodhini, Dhanasekaran; Chidambaram, Manickam; Liju, Samuel; Revathi, Balakannan; Laasya, Dhandapani; Sathish, Natarajan; Kanthimathi, Sekar; Ghosh, Saurabh; Anjana, Ranjit Mohan; Mohan, Viswanathan; and Radha, Venkatesan, "Association of rs11643718 SLC12A3 and rs741301 ELMO1 Variants with Diabetic Nephropathy in South Indian Population" (2016). Journal Articles. 4108.
https://digitalcommons.isical.ac.in/journal-articles/4108
Comments
Open Access; Bronze Open Access