Multi-arm covariate adjusted response adaptive designs for ordinal outcome clinical trials

Authors

Soumyadeep Das, Bidhannagar Government College
Rahul Bhattacharya, University of Calcutta
Atanu Biswas, Indian Statistical Institute, Kolkata

Article Type

Research Article

Publication Title

Statistical Methods in Medical Research

Abstract

Covariate adjusted response adaptive designs are developed with ordinal categorical responses for phase III clinical trial involving multiple treatments. Stochastic ordering principle is used to order the treatments according to effectiveness and consequently allocation functions are developed by combining the cumulative odds ratios suitably. The performance of the proposed designs is investigated through relevant exact as well as large sample measures. To investigate the performance in a real situation, a real clinical trial involving lung cancer patients is further redesigned using the proposed allocation design.

First Page

88

Last Page

99

DOI

https://10.1177/09622802221133558

Publication Date

1-1-2023

Recommended Citation

Das, Soumyadeep; Bhattacharya, Rahul; and Biswas, Atanu, "Multi-arm covariate adjusted response adaptive designs for ordinal outcome clinical trials" (2023). Journal Articles. 4013.
https://digitalcommons.isical.ac.in/journal-articles/4013