ASAPP: Architectural Similarity-Based Automated Pathway Prediction System and Its Application in Host-Pathogen Interactions

Article Type

Research Article

Publication Title

IEEE/ACM Transactions on Computational Biology and Bioinformatics

Abstract

The significance of metabolic pathway prediction is to envision the viable unknown transformations that can occur provided the appropriate enzymes are present. It can facilitate the prediction of the consequences of host-pathogen interactions. In this article, we have proposed a new algorithm Architectural Similarity-based Automated Pathway Prediction (ASAPP) to predict metabolic pathways based on the structural similarity among the metabolites. ASAPP takes two-dimensional structure and molecular weight of metabolites as input, and generates a list of probable transformations without the knowledge of any externally established reactions, with an accuracy of 85.09 percent. ASAPP has also been applied to predict the outcome of pathogen liberated toxins on the carbohydrate and lipid pathways of the hosts. We have analyzed the disruption of host pathways in the presence of toxins, and have found that some metabolites in Glycolysis and the TCA cycle have a high chance of being the breakpoints in the pathway. The tool is available at http://asapp.droppages.com/.

First Page

506

Last Page

515

DOI

10.1109/TCBB.2018.2872527

Publication Date

3-1-2020

Link to Full Text

Share

COinS