INCORPORATING TREATMENT-COVARIATE INTERACTION IN DESIGNING A COVARIATE ADJUSTED RESPONSE ADAPTIVE ALLOCATION FOR BINARY RESPONSE TRIALS

Authors

Rahul Bhattacharya, University of Calcutta
Atanu Biswas, Indian Statistical Institute, Kolkata

Article Type

Research Article

Publication Title

Journal of Statistical Research

Abstract

Assuming binary treatment outcomes, a covariate adjusted response adaptive (CARA) design is developed for multi-arm clinical trials assuming the presence of treatment-covariate interaction. The proposed allocation skews the allocation dynamically according to the performance of the treatments and the covariate profile of any incoming subject. Relevant design and precision based measures of the performance are further investigated empirically, which established the usefulness of the proposed allocation design over its competitors.

First Page

21

Last Page

33

DOI

https://10.3329/jsr.v57i12.72967

Publication Date

5-12-2023

Comments

Open Access, Hybrid Gold

Recommended Citation

Bhattacharya, Rahul and Biswas, Atanu, "INCORPORATING TREATMENT-COVARIATE INTERACTION IN DESIGNING A COVARIATE ADJUSTED RESPONSE ADAPTIVE ALLOCATION FOR BINARY RESPONSE TRIALS" (2023). Journal Articles. 3731.
https://digitalcommons.isical.ac.in/journal-articles/3731