Title

A class of Covariate-Adjusted Response-Adaptive Allocation Designs for Multitreatment Binary Response Trials

Article Type

Research Article

Publication Title

Journal of Biopharmaceutical Statistics

Abstract

A class of covariate-adjusted response-adaptive randomization procedures is developed for binary treatment outcomes in a phase III clinical trial set up involving multiple treatments. The target allocation is developed by combining the ethical aspects with statistical precision under the existence of treatment covariate interaction. Relevant measures of the performance for the proposed allocation designs are studied and compared.

First Page

809

Last Page

823

DOI

10.1080/10543406.2018.1485683

Publication Date

9-3-2018

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