A response adaptive design for ordinal categorical responses

Authors

Atanu Biswas, Indian Statistical Institute, Kolkata
Rahul Bhattacharya, University of Calcutta
Soumyadeep Das, University of Calcutta

Article Type

Research Article

Publication Title

Journal of Biopharmaceutical Statistics

Abstract

A two treatment response adaptive design is developed for phase III clinical trials with ordinal categorical treatment outcome using Goodman-Kruskal measure of association. Properties of the proposed design are studied both empirically and theoretically and the acceptability is further illustrated using two real data-sets; one from a clinical trial with trauma patients and the other from a trial with patients having rheumatoid arthritis.

First Page

1169

Last Page

1181

DOI

10.1080/10543406.2018.1439053

Publication Date

11-2-2018

Recommended Citation

Biswas, Atanu; Bhattacharya, Rahul; and Das, Soumyadeep, "A response adaptive design for ordinal categorical responses" (2018). Journal Articles. 1165.
https://digitalcommons.isical.ac.in/journal-articles/1165