A response adaptive design for ordinal categorical responses
Journal of Biopharmaceutical Statistics
A two treatment response adaptive design is developed for phase III clinical trials with ordinal categorical treatment outcome using Goodman-Kruskal measure of association. Properties of the proposed design are studied both empirically and theoretically and the acceptability is further illustrated using two real data-sets; one from a clinical trial with trauma patients and the other from a trial with patients having rheumatoid arthritis.
Biswas, Atanu; Bhattacharya, Rahul; and Das, Soumyadeep, "A response adaptive design for ordinal categorical responses" (2018). Journal Articles. 1165.