Gland segmentation from histology images using informative morphological scale space
Document Type
Conference Article
Publication Title
Proceedings - International Conference on Image Processing, ICIP
Abstract
Grading of cancer offers insight to the occurrence and progress of the disease. The course of treatment is planned depending on the grade of cancer. Segmentation of the glandular structure of tissue is a prerequisite for grading of colon, prostate and breast cancers. Manual segmentation method is time-consuming and suffers from the curse of observer bias. We propose an automated solution for gland segmentation from hematoxylin & eosin (H&E) stained histology images. Our method relies on the biological cue rather than gland specific signatures that may vary across the slides. We construct a novel informative morphological scale space for gland segmentation. The scale space uses the entropy of the connected components in a novel manner to prevent over segmentation of objects. Our solution is fast, accurate and applicable in a clinical setup. Experiments show an average F1 score of 0.68 for 85 histology images in 20x magnification. We obtain ∼ 30% improvement in F1 score compared to the area morphological scale space method.
First Page
4121
Last Page
4125
DOI
10.1109/ICIP.2016.7533135
Publication Date
8-3-2016
Recommended Citation
Paul, Angshuman and Mukherjee, Dipti Prasad, "Gland segmentation from histology images using informative morphological scale space" (2016). Conference Articles. 723.
https://digitalcommons.isical.ac.in/conf-articles/723
