Design automation of multiple-demand mixture preparation using a K-array rotary mixer on digital microfluidic biochips
Document Type
Conference Article
Publication Title
Proceedings of the 34th IEEE International Conference on Computer Design, ICCD 2016
Abstract
In many biochemical protocols, a mixture of several fluids in a certain ratio is repeatedly required, and hence a sufficient quantity of the mixture must be supplied for on-chip bioassay completion. For example, in polymerase chain reaction (PCR) a premixed and ready-to-use solution, called PCR master mix containing different fluids at optimal concentrations, is used for efficient amplification of DNA templates by PCR. Existing scheduling scheme, namely SRS (storage reduced scheduling), finds a trade-off between time of completion and storage unit requirement depending on the demand while designing a mixing engine using the (1 : 1) mixing model on a digital microfluidic (DMF) biochip. In this paper, we present a scheduling scheme, namely KMS, for optimizing time and storage requirements in multiple-demand mixture preparation using a DMF rotary mixer. The scheduling scheme has been combined with all existing mixing algorithms, namely MinMix, RMA, MTCS and CoDOS to analyze its performance. Simulation results show significant reduction in latency (75%) and storage (48%) requirements by KMS compared with SRS for multiple-demand mixture preparation.
First Page
273
Last Page
280
DOI
10.1109/ICCD.2016.7753290
Publication Date
11-22-2016
Recommended Citation
Kumar, Satendra; Gupta, Ankur; Roy, Sudip; and Bhattacharya, Bhargab B., "Design automation of multiple-demand mixture preparation using a K-array rotary mixer on digital microfluidic biochips" (2016). Conference Articles. 695.
https://digitalcommons.isical.ac.in/conf-articles/695
