Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood 06 Biological Sciences 0604 Genetics

Document Type

Conference Article

Publication Title

BMC Proceedings

Abstract

Complex genetic traits are often characterized by multiple quantitative phenotypes. Because values of such phenotypes vary over time, it is thought that analyses of longitudinal data on the phenotypes may lead to increased power in detecting genetic association. In this paper, we extend a transmission-based association test applying quasi-likelihood that has been developed by us to the longitudinal framework and to carry out a genome-wide association analysis of triglyceride levels based on the data provided in GAW20. We consider different phenotype definitions based on administration of fenofibrate and obtain significant association findings within genes involved in heart diseases.

DOI

10.1186/s12919-018-0147-4

Publication Date

9-17-2018

Comments

Open Access, Gold, Green

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