Prediction of Small RNA and Its Targets in Bacteria.

Date of Submission

December 2011

Date of Award

Winter 12-12-2012

Institute Name (Publisher)

Indian Statistical Institute

Document Type

Master's Dissertation

Degree Name

Master of Technology

Subject Name

Computer Science


Machine Intelligence Unit (MIU-Kolkata)


Bandyopadhyay, Sanghamitra (MIU-Kolkata; ISI)

Abstract (Summary of the Work)

Basic Molecular Biology The main actors in the chemistry of life are molecules are called proteins and nucleic acids. Proteins are responsible for what a living being is and does in a physical sense. Nucleic acids encode information necessary to produce proteins and are responsible for passing along this recipe to subsequent generations. A protein is a chain of simpler molecules called amino acid residues [1]. This sequence is known as its primary structure. Every amino acid has one central carbon atom known as α-carbon. To the Cα (α-carbon) atoms are attached a hydrogen atom, an amino group (NH2), a carboxyl group (COOH) and a side chain. In nature, there are twenty different kinds of amino acids. Examples of amino acids are depicted in Fig 1.1. A protein is not just a linear sequence of residues. Proteins actually fold in three dimensions, presenting secondary, tertiary and quaternary structures. Proteins are produced in a cell structure called ribosome. In ribosome, the component amino acids of a protein are assembled one by one according to information contained in an important molecule called messenger ribonucleic acid [1]. Living organisms contain two kinds of nucleic acids namely ribonucleic acids (RNA) and deoxyribonucleic acids (DNA). 1.1.1 DNA Like protein, DNA is a chain of simpler molecules called the strand. This strand has unit is formed by a sugar molecule called 2’ structure of 2’-deoxyribose is depicted in contains five carbon atoms, and they are labeled 1’ through 5’. The bond backbone is between the 3’ carbon and the 5’ carbon of the next the order 5’-3’. The information necessary to build each protein encoded in the DNA molecules [1] Fig 1.1.2 Bases Attached to each 1’ carbon in the backbone are ot four kinds of bases, Adenine (A), Guanine (G), Cytosine(C) ‘G’ belong to a larger group of substances called purines, where as ‘C’ and ‘T’ belong to the pyrimidines [1].


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Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.


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