Comparative study of anti-staphylococcal efficacy: traditional homeopathic dilutions vs. nano-enhanced Rhus Tox formulations

Article Type

Research Article

Publication Title

Beni Suef University Journal of Basic and Applied Sciences

Abstract

Background: Staphylococcus aureus is a leading cause of death, especially among the elderly. This bacterium produces several surface membrane proteins, with staphylococcal protein A (SpA) being particularly important. Despite its prevalence, there are no targeted treatments available for geriatric patients. In homeopathy, Rhus toxicodendron (RT) is frequently used in various dilutions-Mother Tincture (MT), 6CH, 30CH, and 200CH- for conditions like skin infections, soft tissue disorders, and joint ailments. Methods: In this study, we evaluated the effects of Rhus toxicodendron (RT) at different concentrations on Staphylococcus aureus through bacterial plate cultures and compared the outcomes with Nano-RT. Notably, Nano-RT MT is not commercially available. This research is the first to showcase both the efficacy and biosafety of the innovative nano-ZnO RT MT homeopathic formulation. Results: This study examined the inhibitory effects of Rhus toxicodendron in its Mother Tincture (MT) form and in 6CH, 30CH, and 200CH dilutions against Staphylococcus aureus. Nano-ZnO was synthesized from Rhus toxicodendron MT and combined to create Nano-MT. Both Rhus Tox MT and Nano-RT MT demonstrated significant inhibition of Staphylococcus aureus within 24 h of application. Conclusions: Rhus Tox MT and Nano-RT MT present promising new options for treating Staphylococcus aureus infections in elderly patients. Furthermore, studies have demonstrated that Nano-RT MT is completely biologically safe in mice.

DOI

10.1186/s43088-024-00585-8

Publication Date

12-1-2024

Comments

Open Access; Gold Open Access

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