Bactericidal activity of lactic acid Bacillus in presence of oxide nanoparticles

Article Type

Research Article

Publication Title

Journal of Medical Pharmaceutical and Allied Sciences


The bactericidal activity of human beneficial gut bacteria commonly known as probiotics plays an important role in the era of multidrug-resistant bacteria as the rising antimicrobial resistance has been identified as a top health threat. The probiotic organism plays an important role not only in infection but also in the development of immunity and its impact on inflammatory diseases. Besides digestion and absorption, it eliminates pathogenic microorganisms by their bactericidal activity and thus maintains a proper balance in the gut ecosystem. Along with that, multiple applications of nanotechnology in the agri-food sector, drug delivery, and medical sectors are growing rapidly. The biosafety study of those nanoparticles was tested on several human cell lines, but the fate and behaviour of nanoparticles in the human gastrointestinal tract, especially on beneficial gut flora or probiotics need attention along with its antimicrobial activity. Here, in this study we have tested the effect of titanium dioxide (TiO2), silicon dioxide (SiO2) and zinc oxide (ZnO) nanoparticles (as those nanoparticles used mostly in the agri-food sectors and health sectors) treated Bacillus coagulans (used as probiotic) cellular supernatant on E. coli MTCC 1610 strain with respect to untreated Bacillus coagulans cellular supernatant. We found reduced bactericidal activity in the case of TiO2 and SiO2 nanoparticles treated Bacillus coagulans whereas the bactericidal activity of ZnO nanoparticles treated Bacillus coagulans cellular supernatant showed more or less similar result with respect to untreated Bacillus coagulans cellular supernatant. Hence, the bactericidal activity of nanoparticle-treated Bacillus coagulans was studied thoroughly.

First Page


Last Page




Publication Date



Open Access, Gold

This document is currently not available here.