True endpoint reduction by surrogate endpoints

Article Type

Research Article

Publication Title

Communications in Statistics: Simulation and Computation

Abstract

The use of surrogate endpoint, which is becoming widely popular now a days, was introduced in medical research to reduce the time of experiment required for the approval of a drug. Through cost cutting and time saving, the surrogate endpoints can bring profit to the medicine producers. We obtain the expression for the reduction of true samples, in proportion, at an expense of surrogates to achieve a fixed power while comparing the two treatments. We present our discussion in the two-treatment set up in the context of odds ratio as a measure of treatment difference. We illustrate the methodology with some real dataset.

First Page

6645

Last Page

6653

DOI

10.1080/03610918.2016.1171350

Publication Date

9-14-2017

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