An adaptive allocation design for circular treatment outcome

Article Type

Research Article

Publication Title

Journal of Statistical Theory and Practice

Abstract

A number of allocation designs are developed for continuous and binary treatment outcomes to assign a higher number of subjects to the treatment doing better in course of the trial. However, if the response is circular in nature, the definition of a better treatment differs from that under the linear response and hence the already developed designs lack appropriateness. In the current work, redefining the notions of superiority, we develop an allocation function in the context of circular treatment outcomes. Using a response-adaptive route for practical implementation, we study the resulting design both theoretically and numerically and finally illustrate the performance for a real-life example on cataract surgery.

First Page

719

Last Page

730

DOI

10.1080/15598608.2017.1307147

Publication Date

10-2-2017

This document is currently not available here.

Share

COinS