Temporal variations in country-specific mutational profiles of SARS-CoV-2: Effect on vaccine efficacy

Article Type

Research Article

Publication Title

Future Virology

Abstract

Aim: In order to curb the transmission of SARS-CoV-2, nation-wide travel restrictions at different levels were implemented in different countries. Country-specific mutational profile may exist and have an impact on vaccine efficacy. Materials & methods: We identified nonsynonymous mutations in approximately 215,000 SARS-CoV-2 sequences during the first year of the pandemic in 35 countries. Mutational profiles on a bimonthly basis were traced over time. We also examined the mutations that overlapped with the spike protein vaccine epitopes. Results: Several new mutations emerged over time and were dominating in specific countries. Many nonsynonymous mutations were within multiple spike protein epitopes that might impact the vaccine efficacy. Conclusion: Our study advocates requirement of active monitoring of country-specific mutations and vaccine efficacies in respective countries.

First Page

805

Last Page

819

DOI

10.2217/fvl-2021-0062

Publication Date

12-1-2021

Comments

Open Access, Green

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