Dropclust: Efficient clustering of ultra-large scRNA-seq data
Nucleic Acids Research
Droplet based single cell transcriptomics has recently enabled parallel screening of tens of thousands of single cells. Clustering methods that scale for such high dimensional data without compromising accuracy are scarce. We exploit Locality Sensitive Hashing, an approximate nearest neighbour search technique to develop a de novo clustering algorithm for large-scale single cell data. On a number of real datasets, dropClust outperformed the existing best practice methods in terms of execution time, clustering accuracy and detectability of minor cell sub-types.
Sinha, Debajyoti; Kumar, Akhilesh; Kumar, Himanshu; Bandyopadhyay, Sanghamitra; and Sengupta, Debarka, "Dropclust: Efficient clustering of ultra-large scRNA-seq data" (2018). Journal Articles. 1414.
All Open Access, Gold, Green