Protein structure modeling of abnormal genes associated with PARK 1 and PARK 8 loci related to autosomal dominant parkinson’s disease and docking the protein(s) with appropriate ligands

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Conference Article

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Springer Proceedings in Mathematics and Statistics


Parkinson’s disease (PD) is a common neurological disorder with a prevalence of 1–2 per 1000 overall. PD is of two types: autosomal dominant and recessive, autosomal dominant ones are more harmful—than recessive types—and a single copy of their gene causes the disease. Of the five dominant loci involved in PD—PARK1, PARK3, PARK4, PARK5 and PARK8—the two most predominant are PARK1 and PARK8. Understanding and modeling of the abnormal proteins of these genes of the disease is of importance which can help in drug design and help treating patients of PD disease. In this regard, of these five loci, the protein 3-dimensional structure for alpha-synuclein gene present in PARK 1 locus is known but the abnormal alpha-synuclein proteins causing PD is yet to be modeled. However, no 3-D protein structure for PARK 2 gene present PARK8 locus and the abnormal protein coded by the LARK2 gene are not known. And suitable ligands are also not available for these proteins (Dardarin coded by LRRK2 and alpha-synuclein) that can neutralize the effect in the human brain. We report modeling the PARK1 and PARK8 locus abnormal proteins.

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